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Literature summary for 3.5.1.B15 extracted from

  • Ahmadi, A.; Nazari, R.; Arjomandzadegan, M.; Zolfaghari, M.R.; Vahidi, V.; Poolad, T.; Kahbazi, M.; Sadrnia, M.; Tousheh, M.; Rafiee, P.
    Insights into pyrazinamidase and DNA gyrase protein structures in resistant and susceptible clinical isolates of Mycobacterium tuberculosis (2016), Tanaffos, 15, 147-153 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.B15

Cloned(Commentary)

Cloned (Comment) Organism
gene pncA, genotyping, DNA and amino acid sequence determination and analysis of wild-type and mutants Mycobacterium tuberculosis

Protein Variants

Protein Variants Comment Organism
T92C the naturally occuring mutation causes an increase in distance from metal ion position to enzyme active site, but it is considered as a polymorphism Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pyrazinamide + H2O Mycobacterium tuberculosis
-
 pyrazinoic acid + NH3
-
 ?
pyrazinamide + H2O Mycobacterium tuberculosis H37Rv
-
 pyrazinoic acid + NH3
-
 ?
pyrazinamide + H2O Mycobacterium tuberculosis ATCC 25618
-
 pyrazinoic acid + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis I6XD65
-
-
Mycobacterium tuberculosis ATCC 25618 I6XD65
-
-
Mycobacterium tuberculosis H37Rv I6XD65
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyrazinamide + H2O
-
 Mycobacterium tuberculosis pyrazinoic acid + NH3
-
 ?
pyrazinamide + H2O
-
 Mycobacterium tuberculosis H37Rv pyrazinoic acid + NH3
-
 ?
pyrazinamide + H2O
-
 Mycobacterium tuberculosis ATCC 25618 pyrazinoic acid + NH3
-
 ?

Synonyms

Synonyms Comment Organism
PncA
-
 Mycobacterium tuberculosis
PZAse
-
 Mycobacterium tuberculosis

General Information

General Information Comment Organism
malfunction mutations in the pncA gene cause pyrazinamide (PZA) resistance in Mycobacterium tuberculosis Mycobacterium tuberculosis
additional information structure predictions of wild-type and mutant enzymes from sequences, modeling Mycobacterium tuberculosis